Table 3.
Group differences on cognitive and functional outcomes
PD/RBD+ (n = 58) (a) |
PD/RBD− (n = 65) (b) |
HC (n = 49) (c) |
||||||||
---|---|---|---|---|---|---|---|---|---|---|
Range | Mean/% (SD) | Range | Mean/% (SD) | Range | Mean/% (SD) | F | p | Effect Size |
Post-hoc Comparisons+ |
|
Cognitive Functioning a | ||||||||||
MDRS total score | 124-144 | 137.93 (4.23) | 127-144 | 138.92 (3.17) | 129-144 | 140.71 (3.00) | 4.87 | .009 | a<c | |
Global NP | 25.93-63.29 | 49.41 (7.05) | 34.41-65.48 | 52.90 (5.50) | 43.56-66.41 | 56.29 (6.13) | 10.73 | <.001 | a<b,c | |
Attention/Working memory | 20-57.61 | 44.23 (8.15) | 30-64.20 | 47.18 (7.54) | 34.48-69.94 | 51.47 (8.38) | 7.46 | .001 | a<c | |
Executive Functioning | 23.33-65.75 | 50.05 (8.93) | 38-70 | 53.92 (6.61) | 35.75-70 | 56.02 (7.79) | 5.19 | .007 | a<b,c | |
Language | 34.40-68.72 | 50.44 (8.49) | 25.85-68.72 | 52.24 (8.85) | 40.17-75.67 | 56.97 (6.99) | 6.67 | .002 | a,b<c | |
Learning | 28.67-65.67 | 49.82 (9.60) | 39.33-72 | 54.31 (7.71) | 40.33-72 | 57.85 (8.33) | 7.82 | .001 | a<b,c | |
Memory | 29.33-67.67 | 51.30 (8.04) | 20-70.67 | 54.84 (7.83) | 41-75.67 | 58.80 (8.45) | 7.28 | .001 | a<c | |
Visuospatial functioning |
15.92-66.53 | 51.43 (9.03) | 15.05-69.25 | 55.60 (9.51) | 36.52-69.25 | 57.28 (8.52) | 4.10 | .018 | a<c | |
Functional Capacity | ||||||||||
MMAAb | 0-33 | 28.58 (6.60) | 4-33 | 30.06 (5.03) | 27-33 | 31.57 (1.73) | H = 6.24 | .044 | a<c | |
UPSA (Finance subscale)b | 1-11 | 9.79 (1.62) | 7-11 | 10.03 (0.93) | 7-11 | 10.24 (0.72) | H = 2.18 | .336 | -- | |
IADLa | 3-16 | 13.45 (2.90) | 8-16 | 14.41 (1.99) | 12.73-20 | -- | 2.66 | .106 | -- |
Bold font denotes p<.05. MDRS=Mattis Dementia Rating Scale; Global NP=global neuropsychological performance (calculated as an average of all individual cognitive measures); MMAA= Medication Management Abilities Assessment; UPSA= UCSD Performance-Based Skills Assessment; IADL=Instrumental Activities of Daily Living Scale. All cognitive domains report results using T-scores (M±SD=50±10, range 20–80), except for MDRS total score, which is expressed as a total raw score (range 0-144).
Statistics reported from models controlling for psychiatric symptom severity (depression, trait anxiety, apathy).
Non-parametric Kruskal-Wallis Test
Bonferroni adjustment for multiple comparisons