Notable results from the 24 month cohort of GHR−/− mice. A. Body weight p<0.0001, t=12.95, df=12. B. Body composition expressed as percent of body weight: Fat p<0.0001, t=5.815, df=12; lean p=0.0006, U=0; fluid p=0.0024 t=3.826, df=12. C. Serum cytokine levels: IL-6 p=0.6402, U=27; MCP-1 p=0.2092, Welch-corrected t=1.356, df=8.704; TNF-α p=0.4462, U=24.5. D. Number of CD3+CD8+ cytotoxic T cells, reported as the mean of the number of cells per gram of tissue ± SEM: SubQ p=0.0105, U=5.5; Epi p=0.7523, U=18.5. WT n = 8 and GHR−/− n = 8. * indicates a significant difference; p < 0.05.