Table 4.
Multivariable-adjusted1 odds ratio (95% confidence interval) of fibroids according to tertiles of erythrocyte fatty acid concentration among 553 participants (56 fibroids cases, 497 non-cases), Nurses' Health Study II
| T1 | T2 | T3 | ptrend2 | pcontinuous3 | |
|---|---|---|---|---|---|
| Total Saturated Fatty Acids | 1.00 (Referent) | 0.94 (0.45-1.95) | 1.12 (0.55-2.27) | 0.70 | 0.51 |
| Lauric acid (12:0) | 1.00 (Referent) | 0.98 (0.48-2.00) | 0.92 (0.45-1.87) | 0.81 | 0.66 |
| Mystristic acid (14:0) | 1.00 (Referent) | 0.83 (0.40-1.74) | 1.05 (0.52-2.10) | 0.82 | 0.88 |
| Pentadecanoic acid (15:0) | 1.00 (Referent) | 0.62 (0.29-1.32) | 1.07 (0.54-2.15) | 0.78 | 0.39 |
| Palmitic acid (16:0) | 1.00 (Referent) | 1.15 (0.58-2.30) | 0.92 (0.44-1.93) | 0.83 | 0.68 |
| Margric acid (17:0) | 1.00 (Referent) | 1.60 (0.75-3.43) | 1.85 (0.85-4.03) | 0.15 | 0.07 |
| Stearic acid (18:0) | 1.00 (Referent) | 1.02 (0.49-2.12) | 1.22 (0.59-2.49) | 0.56 | 0.08 |
| Nonadecanoic acid (19:0) | 1.00 (Referent) | 1.27 (0.57-2.81) | 2.08 (0.97-4.46) | 0.05 | 0.19 |
| Arachidic acid (20:0) | 1.00 (Referent) | 1.03 (0.50-2.15) | 1.17 (0.57-2.40) | 0.66 | 0.46 |
| Behenic acid (22:0) | 1.00 (Referent) | 0.94 (0.46-1.92) | 1.01 (0.49-2.07) | 0.96 | 0.55 |
| Tricosanoic acid (23:0) | 1.00 (Referent) | 0.96 (0.48-1.90) | 0.63 (0.29-1.35) | 0.22 | 0.50 |
| Lignoceric acid (24:0) | 1.00 (Referent) | 0.59 (0.29-1.19) | 0.68 (0.34-1.36) | 0.26 | 0.21 |
| Total Monounsaturated Fatty Acids | 1.00 (Referent) | 0.78 (0.39-1.57) | 0.64 (0.30-1.36) | 0.24 | 0.12 |
| Mysristoleic acid (14:1n-5c) | 1.00 (Referent) | 0.96 (0.46-2.02) | 1.22 (0.60-2.47) | 0.53 | 0.54 |
| Pentadecenoic acid (15:1n-5c) | 1.00 (Referent) | 0.83 (0.42-1.64) | 0.55 (0.25-1.23) | 0.15 | 0.06 |
| Palmitoleic acid (16:1n-7c) | 1.00 (Referent) | 0.92 (0.47-1.80) | 0.48 (0.21-1.10) | 0.08 | 0.05 |
| Oleic acid (18:1n-9c) | 1.00 (Referent) | 0.39 (0.18-0.84) | 0.60 (0.30-1.23) | 0.11 | 0.46 |
| Octadecenoic acid (18:1n-7c) | 1.00 (Referent) | 2.24 (1.09-4.63) | 1.19 (0.53-2.71) | 0.77 | 0.94 |
| Gondoic acid (20:1n-9c) | 1.00 (Referent) | 2.03 (0.99-4.18) | 0.96 (0.43-2.15) | 0.88 | 0.58 |
| Nervonic acid (24:1n-9c) | 1.00 (Referent) | 1.01 (0.52-1.99) | 0.65 (0.30-1.38) | 0.28 | 0.18 |
| n-3 Polyunsaturated Fatty Acids | 1.00 (Referent) | 0.49 (0.24-0.97) | 0.41 (0.19-0.89) | 0.02 | 0.02 |
| Alpha-linolenic acid (ALA, 18:3n-3c) | 1.00 (Referent) | 1.69 (0.84-3.40) | 0.75 (0.34-1.69) | 0.40 | 0.74 |
| Eicosapentaenoic acid (EPA, 20:5n-3c) | 1.00 (Referent) | 0.64 (0.32-1.25) | 0.42 (0.19-0.90) | 0.03 | 0.01 |
| Docosapentaenoic acid (DPA, 22:5n-3c) | 1.00 (Referent) | 0.60 (0.29-1.22) | 0.73 (0.36-1.48) | 0.34 | 0.11 |
| Docosahexaenoic acid (DHA, 22:6n-3c) | 1.00 (Referent) | 0.40 (0.19-0.85) | 0.57 (0.28-1.15) | 0.09 | 0.03 |
| n-6 Polyunsaturated Fatty Acids | 1.00 (Referent) | 0.93 (0.44-1.92) | 1.14 (0.57-2.29) | 0.74 | 0.81 |
| Linoleic acid (18:2n-6cc) | 1.00 (Referent) | 0.94 (0.45-1.93) | 1.09 (0.53-2.23) | 0.81 | 0.58 |
| Gamma-linolenic acid (18:3n-6c) | 1.00 (Referent) | 0.85 (0.42-1.73) | 0.83 (0.40-1.75) | 0.65 | 0.29 |
| Eicosadienoic acid (20:2n-6c) | 1.00 (Referent) | 1.05 (0.51-2.13) | 1.04 (0.51-2.15) | 0.92 | 0.95 |
| Dihomogammalinolenic acid (20:3n-6c) | 1.00 (Referent) | 0.60 (0.29-1.23) | 0.70 (0.34-1.42) | 0.33 | 0.11 |
| Arachidonic acid (20:4n-6c) | 1.00 (Referent) | 0.62 (0.30-1.29) | 0.90 (0.45-1.80) | 0.76 | 0.79 |
| Docosadienoic acid (22:2n-6c) | 1.00 (Referent) | 0.85 (0.38-1.89) | 1.86 (0.90-3.84) | 0.05 | 0.05 |
| Aolrenic acid (22:4n-6c) | 1.00 (Referent) | 1.12 (0.55-2.29) | 1.03 (0.50-2.12) | 0.93 | 0.42 |
| Total Trans Fatty Acids | 1.00 (Referent) | 1.23 (0.52-2.92) | 3.33 (1.50-7.38) | 0.002 | 0.004 |
| Palmitelaidic acid (16:1n-7t) | 1.00 (Referent) | 0.90 (0.42-1.92) | 1.42 (0.68-2.99) | 0.30 | 0.10 |
| Linolelaidic acid (18:2n-6t) | 1.00 (Referent) | 1.87 (0.81-4.29) | 2.87 (1.30-6.34) | 0.008 | 0.04 |
| Octadecadienoic acid (18:2n-7c) | 1.00 (Referent) | 0.86 (0.41-1.81) | 1.26 (0.63-2.52) | 0.48 | 0.59 |
| 18:1 trans | 1.00 (Referent) | 1.14 (0.48-2.71) | 3.10 (1.42-6.77) | 0.003 | 0.002 |
| 18:2 trans | 1.00 (Referent) | 1.31 (0.61-2.81) | 1.64 (0.78-3.46) | 0.19 | 0.34 |
| Dairy-derived Fatty Acids | 1.00 (Referent) | 1.26 (0.58-2.72) | 1.68 (0.79-3.59) | 0.17 | 0.10 |
| Industrial trans | 1.00 (Referent) | 1.08 (0.46-2.56) | 3.06 (1.41-6.66) | 0.002 | 0.003 |
| Total n-6/n-3 Ratio | 1.00 (Referent) | 1.23 (0.55-2.74) | 1.94 (0.91-4.16) | 0.08 | 0.03 |
| SI ration-7 | 1.00 (Referent) | 2.03 (0.90-4.56) | 2.10 (0.90-4.86) | 0.10 | 0.05 |
| SI ration-9 | 1.00 (Referent) | 1.19 (0.57-2.46) | 1.21 (0.58-2.52) | 0.62 | 0.09 |
1
Adjusted for age (continuous), blood draw time (1a-8, 9a-12p, 1-mid), fasting status (yes/no), blood draw season (Nov-Apr, May-Oct), race (white, nonwhite), parity (nulliparous, 1, 2, 3, 4+), age at first birth (<25, 25-30, 31+), time since last birth (<6, 6-12, 13+ years), age at menarche (<12, 12-13, 14+), menstrual cycle length (<26, 26-31, 32+ days), and body mass index (<20, 20-21.9, 22-23.9, 24-24.9, 25-26.9, 27-29.9, 30+).
2
Determined using category medians.
3
Determined using a continuous variable.