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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Biol Psychiatry. 2020 Apr 13;88(9):698–709. doi: 10.1016/j.biopsych.2020.03.021

Figure 3. Serotonin Agonists and Antagonists Reveal a 5-HT-1A Mechanism for Suppression.

Figure 3.

Repo>Dube3a flies were assayed for bang sensitivity (total recovery time in seconds) after being raised on food containing solvent alone (water or EtOH) versus increasing concentrations of various 5-HT1A agonists and antagonists. A) All compounds that act either as 5-HT1A agonists (Serotonin HCl, U92016A and Ketanserin Tartrate) or are antagonists to 5-HT2A receptor (Mirtazapine) significantly suppressed seizures in repo>Dube3a animals at concentrations down to 0.04μM in the food. B) All compounds that are 5-HT1A antagonists (Mianserin HCl, R(DOI) HCl, WAY100635) significantly enhanced seizure recovery time at concentrations between 0.04–0.2μM. Green lines are average recovery time in water or EtOH. Error bars (red) are SEM. N>60 animals per data point. All flies in this figure were female, males showed similar results (Figure S6).