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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Biol Psychiatry. 2020 Apr 13;88(9):698–709. doi: 10.1016/j.biopsych.2020.03.021

Figure 4.

Figure 4.

Complete rescue of seizure phenotype in repo>Dube3a animals. A) Expression of ATPα with 5HT treatment significantly decreases recovery time from >85s to <20s on average. B) Expression of ATPα with L-dopa treatment significantly decreases recovery time from >85s to <20s on average. C) Expression of ATPα with 5HT + L-dopa treatment significantly decreases recovery time from >80s to <1s on average. Most animals had no seizures at all. The green line is 30s, the minimum recover time for all repo>Dube3a flies we used for primary screening. Error bars are SEM. N>20 animals per column.