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. Author manuscript; available in PMC: 2021 Mar 23.
Published in final edited form as: Nature. 2020 Sep 23;586(7828):281–286. doi: 10.1038/s41586-020-2745-3

Extended Data Fig. 5|. Effects of maternal antibiotic treatment and gestational conventionalization on the fecal microbiota.

Extended Data Fig. 5|

a, Bacterial load of the maternal fecal microbiota in response to antibiotic (ANVM=ampicillin, neomycin, vancomycin, metronidazole) treatment and conventionalization with SPF microbiota. Yellow line=Ct of germ-free control. (n=5 cages). b, Principal coordinate analysis of 16S rRNA gene sequencing data (weighted Unifrac distances) for maternal fecal microbiota prior to antibiotic treatment (pre-ABX), on Day 2, 4, or 6 after ABX treatment, and on Day 0 (E14.5), 4 (E18.5), 6 (P2) and 8 (P4) after exposure to SPF bedding. (n=5, 5, 5, 5, 3 cages). c, Class-level taxonomic diversity of maternal fecal microbiota pre-ABX and on Day 0 (E14.5), 4 (E18.5), 6 (P2) and 8 (P4) after exposure to SPF bedding. (n=5, 5, 5, 5, 3 cages).