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. Author manuscript; available in PMC: 2021 Feb 17.
Published in final edited form as: Nat Struct Mol Biol. 2020 Aug 17;27(10):901–912. doi: 10.1038/s41594-020-0475-8

Extended Data Figure 8. Estimation of secondary motif-dependent Rbfox events across neuronal cell types.

Extended Data Figure 8.

In a comparison of neuronal cell types with medium to highest Rbfox mRNA expression, exons likely to be regulated by Rbfox are significantly (P < .0084 Fisher’s exact test, ndown = 13; nup = 28) enriched in secondary motifs. Of 864 alternative exons with increased splicing, 11% are primary, 26.4% primary and secondary, and 3.2% are 4+ secondary motif-associated. Exons with one to three secondary motif instances are also significantly enriched (P < 0.0012, Fisher’s exact test, ndown = 263; nup = 354).