Figure 2.
Time-course of pharmacodynamic effects induced by s.c. saline or U-47700 (0.3, 1.0, and 3.0 mg/kg) in male rats. Hot plate latency, catalepsy score, and core body temperature are presented as mean±SEM for N=6 rats in saline, 0.3, and 1.0 mg/kg groups, and N=5 rats in the 3.0 mg/kg group. Filled symbols represent significant differences when compared to saline-treated group at a given time point (p<0.05, Tukey’s).