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Time-concentration profiles for U-47700, N-desmethyl-U-47700 (N-desmethyl), and N,N-didesmethyl-U-47700 (N,N-didesmethyl) after s.c. injection of U-47700. Findings presented in Figure 3 are from the same rats depicted in Figure 2. Data are mean±SEM for N=6 rats in the 0.3 and 1.0 mg/kg groups, and N=5 rats in the 3.0 mg/kg group. Filled symbols represent significant differences when compared to the low dose (0.3 mg/kg) group at a given time point (p<0.05, Tukey’s).
