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Comparison of expected versus observed AUC values for U-47700, N-desmethyl-U-47700 (N-desmethyl), and N,N-didesmethyl-U-47700 (N,N-didesmethyl) after s.c. administration of U-47700. Expected values for the 1.0 and 3.0 doses were calculated by multiplying the observed AUC values at 0.3 mg/kg U-47700 by a factor of 3.3 and 10, respectively. Data are mean±SEM. * = significant difference from corresponding expected value (p<0.05).
