Table 1.

Pharmacokinetic constants for U-47700 and its N-desmethyl metabolites after s.c. administration of 0.3, 1.0, or 3.0 mg/kg U-47700 in male rats.

Analyte	Dose (mg/kg)	Cmax (ng/mL)	Tmax (min)	AUC (min*ng/mL)	t1/2 (min)	Clast (ng/mL)
U-47700	0.3	40±3	15	2169±164	82±9	0.2±0.1
	1.0	110±13	38±17	9872±1063	68±4	0.8±0.3
	3.0	173±9	24±9	26692±2861	102±16	8±4
N-Desmethyl-U-47700	0.3	9±4	80±13	1289±306	110±7	0.4±0.1
	1.0	46±11	75±15	8158±1526	136±17	4±1
	3.0	102±23	168±29	33881±8794	-	76±31
N,N-Didesmethyl-U-47700	0.3	32±11	90±13	6427±1890	126±10	3±1
	1.0	108±26	160±25	34463±9920	301±84	32±17
	3.0	236±31	384±59	69834±5492	-	191±46

Data are expressed as mean±SEM for N=5–6 rats/group.