Table 34.
Clinical signs—other organ systems.
| N (%)a | |
|---|---|
| Metabolic | 714 (10.0) |
| Elevated anion gap (> 20) | 299 (4.2) |
| Metabolic acidosis (pH < 7.2) | 268 (3.7) |
| Hypoglycemia (glucose <50 mg/dL) | 113 (1.6) |
| Elevated osmole gap (> 20) | 34 (0.5) |
| Renal/musculoskeletal | 549 (7.6) |
| Acute kidney injury (creatinine > 2.0 mg/dL) | 308 (4.3) |
| Rhabdomyolysis (CPK > 1000 IU/L) | 241 (3.4) |
| Hematological | 397 (5.5) |
| Coagulopathy (PT > 15 s) | 141 (2.0) |
| Leukocytosis (WBC > 20 K/μL) | 90 (1.3) |
| Thrombocytopenia (platelets < 100 K/μL) | 79 (1.1) |
| Hemolysis (Hgb < 10 g/dL) | 59 (0.8) |
| Methemoglobinemia (MetHgb ≥ 2%) | 19 (0.3) |
| Pancytopenia | 9 (0.1) |
| Gastrointestinal/hepatic | 323 (4.5) |
| Hepatotoxicity (AST ≥ 1000 IU/L) | 199 (2.8) |
| Pancreatitis | 54 (0.8) |
| Gastrointestinal bleeding | 45 (0.6) |
| Corrosive injury | 22 (0.3) |
| Intestinal ischemia | 3 (0.0) |
| Dermatological | 230 (3.2) |
| Rash | 115 (1.6) |
| Blister/bullae | 75 (1.0) |
| Necrosis | 31 (0.4) |
| Angioedema | 9 (0.1) |
CPK creatine phosphokinase, PT prothrombin time, WBC white blood cells, AST aspartate aminotransferase
aPercentage equals the number of cases reporting specific clinical signs compared to the total number of Registry cases in 2019 (N = 7177). Cases may be associated with more than one sign or symptom