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. 2020 Sep 30;8:587866. doi: 10.3389/fcell.2020.587866

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Copyright © 2020 Kassem and Kamal.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A schematic presentation for the different types of mesenchymal stem cells and their various therapeutic strategies implicated in COVID-19 treatment. MSCs and their derived EVs can efficiently intervene via several mechanisms to improve the overall outcome of COVID-19 especially in critically-ill patients with severe symptoms. These mechanisms include their immunomodulatory activities, tissue regenerative effects, anti-microbial effects, as well as their antifibrotic and angiogenic effects. AD, Adipose tissue; BM, Bone marrow; COVID-19, Corona Virus Disease-2019; EVs, Extra-Cellular vesicles; MSCs, Mesenchymal Stem Cells; and WJ, Wharton’s Jelly. Created by Biorender.com.