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. 2020 Sep 30;8:563316. doi: 10.3389/fcell.2020.563316

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Copyright © 2020 Liu, Tang, Yang, Deng, Xu, Xu, Peng, Wang, Fang, Kuang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A proposed model of two Oct4 isoforms involved in the endothelium-oriented transition of LCSCs. Oct4 regulates the TECs transition of LCSCs by at least two means: LCSCs trans-differentiate into TECs regulated by Oct4A, which play a crucial role in the maintenance of pluripotency of LCSCs; on the other hand, LCSCs can lineage-restricted differentiate into TECs directly through the positive regulation of Oct4B1. In addition, Oct4A may negatively regulate Oct4B1 by nucleocytoplasmic shutting.