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. 2020 Sep 30;8:579629. doi: 10.3389/fcell.2020.579629

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Copyright © 2020 Zhang, Liang, He, He, Yue, Jin, Gao, Xiao and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fra-1 suppressed metabolic reprogramming in cervical cells. (A) Western blot analysis of the expression of key glycolysis enzymes PFK1, PKM2, and PDH in HeLa/vector and HeLa/Fra-1 cells. (B) Real-time polymerase chain reaction (PCR) analysis of the expression of glycolysis enzymes GLUT1, HK II, and LDHA in HeLa/vector and HeLa/Fra-1 cells. (C) Lactate concentration in HeLa/vector and HeLa/Fra-1 cells. (D) Glucose concentration in HeLa/vector and HeLa/Fra-1 cells. (E) Glutamine dehydrogenase (GDH) protein level and glutamine concentration in HeLa/Fra-1 and HeLa/vector cells. *P < 0.05; **P < 0.01; ***P < 0.001, n = 3.