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. 2020 Sep 16;22:445–455. doi: 10.1016/j.omtn.2020.09.007

Figure 5.

Figure 5

miR-145-5p Played Tumor-Suppressive Roles in HCC

(A) miR-145-5p was significantly downregulated in HCC cell lines compared with normal liver cell lines. (B) miR-145-5p expression in HCC tissues was lower than that in normal tissues. (C) miR-145-5p expression was negatively correlated with hsa_circ_0001955 expression in 60 HCC tissues. (D) Transfection effect of miR-145-5p mimic and inhibitor in SMMC7721 and HCCLM3. (E) Overexpression of miR-145-5p suppressed cell growth, whereas knockdown of miR-145-5p promoted cell growth in HCC. (F) Overexpression of miR-145-5p suppressed SMMC7721 migration, whereas knockdown of miR-145-5p promoted migration. (G) Overexpression of miR-145-5p suppressed HCCLM3 migration, whereas knockdown of miR-145-5p promoted migration. (H) Overexpression of miR-145-5p suppressed SMMC7721 invasion, whereas knockdown of miR-145-5p promoted invasion. (I) Overexpression of miR-145-5p suppressed HCCLM3 invasion, whereas knockdown of miR-145-5p promoted invasion. ∗p < 0.05.