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. 2020 Sep 16;22:445–455. doi: 10.1016/j.omtn.2020.09.007

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© 2020 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

NRAS Was a Direct Target of the hsa_circ_0001955/miR-145-5p Axis in HCC

(A) The top 10 enriched KEGG pathways of target genes of miR-145-5p. (B) The intersection of genes enriched in four selected pathways. (C) The expression levels of six genes in HCC. (D) The prognostic values of six genes in HCC. (E) The expression correlation between miR-145-5p and six genes in HCC. (F) The description of expression, survival, and correlation analyses for the six genes in HCC. (G) NRAS was identified as the potential target of miR-145-5p based on the analytic results from expression, survival, and correlation analyses. (H) The direct relationship between miR-145-5p and NRAS was determined by dual-luciferase reporter assay. (I) The expression change of NRAS after alteration of hsa_circ_0001955 and miR-145-5p. ∗p < 0.05. ns, represented 99999no significant difference.