TABLE 3.
Antifungal activity of the peptides.
|
MIC (μM)a |
|||||||||||
| KV | KV2 | KV3 | RV3 | KF3 | KW3 | RF3 | RW3 | Melittin | FLUb | AmBc | |
| C. albicans cgmcc 2.2086 | >64 | >64 | 32 | 32 | 32 | 4 | 8 | 4 | 4 | 2 | 1 |
| C. albicans 56452 | >64 | >64 | 32 | 16 | 16 | 4 | 8 | 4 | 8 | >256 | 1 |
| C. albicans 56214 | >64 | >64 | 32 | 16 | 16 | 4 | 4 | 2 | 4 | >256 | 1 |
| C. albicans 14936 | >64 | >64 | >64 | 32 | 64 | 8 | 8 | 4 | 4 | 32 | 0.25 |
| C. albicans 17546 | >64 | >64 | 64 | 64 | 64 | 8 | 8 | 8 | 8 | >256 | 0.25 |
| C. albicans 58288 | >64 | >64 | 64 | 32 | 32 | 8 | 8 | 4 | 4 | 8 | 0.5 |
| C. albicans sp3902 | >64 | >64 | 64 | 32 | 16 | 2 | 8 | 2 | 2 | 16 | 0.25 |
| C. albicans sp3903 | >64 | >64 | 64 | 32 | 32 | 4 | 8 | 2 | 4 | 16 | 0.13 |
| C. albicans sp3931 | >64 | >64 | 64 | 32 | 32 | 8 | 8 | 4 | 8 | 1 | 0.25 |
| C. albicans sp3876 | >64 | >64 | 16 | 32 | 64 | 8 | 4 | 4 | 4 | >256 | 0.25 |
| C. tropicalis cgmcc 2.1975 | >64 | >64 | 16 | 8 | 8 | 2 | 8 | 2 | 4 | 4 | 1 |
| C. parapsilosis cgmcc 2.3989 | >64 | >64 | 32 | 16 | 32 | 8 | 16 | 4 | 2 | 4 | 2 |
aAntifungal activity of the peptides was determined using minimum inhibitory concentration (MIC). MIC was representative consensus value of at least three independent experiments, each performed in triplicate. bFluconazole (FLU) is a conventional triazole antifungal agent. cAmphotericin B (AmB) is a conventional polyene antifungal agent.