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. 2020 Sep 30;11:565257. doi: 10.3389/fimmu.2020.565257

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Copyright © 2020 Pagel, Twisselmann, Rausch, Waschina, Hartz, Steinbeis, Olbertz, Nagel, Steinmetz, Faust, Demmert, Göpel, Herting, Rupp and Härtel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Suppressive capacity of regulatory T cells (Tregs) derived from preterm infants on the proliferation of CD4+ CD25- T cells was significantly stronger after 4 days of co-culture compared to Tregs from term infants and adults. (A) Proliferation rate of CD4+ CD25– T cells after 4 days of co-culture with Tregs from adults, term and preterm infants in a 1:1 or 2:1 ratio. The positive control was generated without Tregs. Proliferation was determined via CFSE signal using flow cytometry. (B) Representative stagged histograms show the negative staining control (-CFSE) with beads, the negative proliferation control (+CFSE) without beads, and the positive proliferation control (+CFSE, +Beads) without suppressive Tregs (ANOVA followed by Šidák-Holm, p-values are presented in the figure).