Table 2.
Results of the generalized estimating equation (GEE) models to determine the association between Treg frequencies on different postnatal timepoints with clinical parameters.
| Estimate | SE | 95% CI | p-value | Adjusted type I error level | ||
|---|---|---|---|---|---|---|
| Gestational age | −0.277 | 0.054 | −0.383 | −0.172 | <0.0001 | |
| Timepoint | 0.313 | 0.093 | 0.131 | 0.495 | 0.001 | |
| LOS | 0.475 | 0.796 | −1.086 | 2.036 | 0.551 | |
| BPD | 1.953 | 0.788 | 0.408 | 3.498 | 0.013 | |
| EOS | 0.684 | 0.869 | −1.020 | 2.388 | 0.431 | |
| AIS | −0.395 | 0.370 | −1.121 | 0.331 | 0.287 | |
| Interactions | ||||||
| Timepoint × LOS | −0.428 | 0.188 | −0.797 | −0.059 | 0.023 | 0.0102 |
| Timepoint × BPD | −0.657 | 0.212 | −1.073 | −0.241 | 0.002 | 0.0073 |
| Timepoint × EOS | −0.135 | 0.243 | −0.611 | 0.341 | 0.579 | 0.050 |
| Timepoint × AIS | −0.085 | 0.131 | −0.341 | 0.171 | 0.517 | 0.0253 |
| LOS × BPD | −2.986 | 1.253 | −5.440 | −0.531 | 0.017 | |
| Timepoint × LOS × BPD | 1.175 | 0.389 | 0.413 | 1.938 | 0.003 | 0.0025 |
Gestational age was included as confounder. Interaction effects of timepoint and AIS, timepoint and EOS, timepoint and LOS, timepoint and BPD, as well as timepoint and LOS and BPD, were tested (AIS, amniotic infection syndrome; EOS, early-onset sepsis; LOS, late-onset sepsis; BPD, bronchopulmonary dysplasia (need for supplemental oxygen > 28 days); type I error level was adjusted for 5 of 10 tests with Šidák-Holm; CI, confidence interval; SE, standard error)..