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. 2020 Sep 30;8:523550. doi: 10.3389/fcell.2020.523550

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Copyright © 2020 Rajak, Iannucci, Zhou, Anjum, George, Singh, Ghosh, Yen and Sinha.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ULK1 regulates mevalonate/cholesterol biosynthesis pathway gene expression in mouse liver. (A) Representative immunoblot showing silencing efficiency of ULK1 in mouse liver treated with hydrodynamic tail vein delivered ± Ulk1 siRNA (40 ug/72 h). (B) Microarray derived transcriptomic pathway analysis in mouse liver upon Ulk1 KD as described above. (C) qRT-PCR validation of mevalonate/cholesterol biosynthesis pathway genes ± Ulk1 siRNA (40 ug/72 h) in AML12 mouse liver. Values are means ± SD (n = 4), ^∗p < 0.05. (D) Total cholesterol content in hepatic lipid extracts in mouse liver ± Ulk1 siRNA (40 ug/72 h). Values are means ± SD (n = 4, *p < 0.05).