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Effect of mucins on non-oxidative killing by cationic peptides and proteins. (A) Recombinant human neutrophil lysozyme (6 µg/ml) effectively killed P. aeruginosa bacteria and (B) the addition of chondroitin to lysozyme protected bacteria (n = 4). Airway mucins purified from CF mucus also protected P. aeruginosa against killing by (C) 4 µg/ml of HBD-2 and (D) neutrophil granule extracts containing 8 µg/ml of lysozyme (n = 4 (*p < 0.05, **p < 0.01).
