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. 2020 Sep 30;11:590787. doi: 10.3389/fphys.2020.590787

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Copyright © 2020 Tamanna, Clifton, Rae, van Helden, Lumbers and Pringle.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Plasma levels and activity of ACE, ACE2, and NEP in non-pregnant (NP) and pregnant women (A–D). Plasma levels of Ang-(1-7) were measured by radioimmunoassay in NP and pregnant women (E). Plasma ACE2/ACE ratio and ACE2 activity/ACE ratio in NP and pregnant women (F,G). Data are expressed as median and interquartile range. n = 9–10 samples for the NP group (black box), n = 7–35 samples/group for 13, 18, 30, and 36 weeks of normal pregnancy (white box). P-values were calculated using a Kruskal–Wallis test (with Dunn’s multiple comparison test). *P < 0.05, **P < 0.01, ***P < 0.001 versus NP.