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. 2020 Sep 30;11:590787. doi: 10.3389/fphys.2020.590787

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Copyright © 2020 Tamanna, Clifton, Rae, van Helden, Lumbers and Pringle.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Plasma levels and activity of (A) ACE, (B,C) ACE₂, and (D) NEP as well as levels of (E) Ang-(1-7), (F) ACE2/ACE ratio, and (G) ACE2 activity/ACE2 ratio in normal and SGA pregnancies. Data are expressed as median and interquartile range. n = 5–36 samples/group for normal pregnancies (gray box) and n = 4–15 samples/group for SGA pregnancies (white box). P-values were calculated using a two-way ANOVA (mixed effect model with Fisher’s LSD multiple comparison test). ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001 versus normal pregnancy group of the same gestational age.