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Schematic representation of V. cholerae H-NS mediated negative modulation virulence and biofilm expression. Apart from the ctxAB operon, most of the genes are silenced by H-NS is located in the tcp, rtx gene clusters, vas T6SS operon, hlyA hemolysin/cytolysin, and the vps biofilm utilization genes at low c-di-GMP. Lines with base near the intergenic regions represent H-NS repression. Red arrow indicates activation of corresponding genes.
