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Immunoregulation of the testis is mediated by a combination of structural (blood- testis barrier) and cellular derived factors. Illustration shows in a rodent testis, resident macrophages, tolerogenic dendritic cells, T cells and mast cells in the interstitium interacting with Leydig, Sertoli and peritubular cells releasing factors to create an optimal microenvironment for germ cells. Under inflammatory conditions immune cells are able to respond to invading pathogens.
