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. 2020 Sep 30;11:566611. doi: 10.3389/fphar.2020.566611

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Copyright © 2020 Tu, Fang, Sun, Liu, Liu, Wu, Yee, Yuan, Wang, Wan, Tang, Wan and Tang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of TFA and FEB on renal injury. (A) Photomicrographs of periodic acid-Schiff (PAS) staining and Masson’s trichrome staining in the Normal, Model, TFA, and FEB rat groups. Scale bar: 100 μm. (B) Fibrosis area. (C) A WB analysis of α-SMA and collagen I in the kidneys of the Normal, Model, TFA, and FEB rats. The data are expressed as the mean ± SD, (n = 3). ^* P < 0.05, ^** P < 0.01. TFA, total flavones of Abelmoschus manihot; FEB, febuxostat; α-SMA, α-smooth muscle actin; WB, Western blotting; SD, standard deviation.