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. 2020 Sep 30;11:566611. doi: 10.3389/fphar.2020.566611

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Copyright © 2020 Tu, Fang, Sun, Liu, Liu, Wu, Yee, Yuan, Wang, Wan, Tang, Wan and Tang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of TFA and FEB on macrophage polarization in vivo. (A, B) Immunofluorescence staining of iNOS and CD163 in the kidneys of the Normal, Model, TFA, and FEB rats. Scale bar: iNOS, 100 μm; CD163, 50 μm. (C–E) Immunohistochemical staining of IL6, CD206, and ARG1 in the kidneys of the Normal, Model, TFA, and FEB rats. Scale bar: 100 μm. *P < 0.05, **P < 0.01. TFA, total flavones of Abelmoschus manihot; FEB, febuxostat; iNOS, inducible nitric oxide synthase; IL6, interleukin 6; ARG1, arginase 1.