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CRISPR/Cas9 Strategy for Relieving miRNA Driven Post Transcriptional Repression and Increased Expression of Utrophin
The schematic summarizes our CRISPR/Cas9 genome editing strategy to delete the IMTR from the UTRN 3′ UTR with the rationale that the edited UTRN 3′ UTR (UTRNΔIMTR) would reduce miRNA-mediated post-transcriptional repression and lead to higher expression of utrophin.
