FIG 9.

GprM and GprJ are important for the regulation of genes encoding proteins involved in secondary metabolite (SM) biosynthesis. Heat map depicting the log₂ fold change of differentially expressed genes (DEGs), as determined by RNA-seq, and encoding enzymes required for specific SM biosynthesis. Log₂FC values are based on comparisons between the mpkB (control), gprM and gprJ deletion strains, and the wild-type strain; as well as between the gprM- and gprJ-overexpressing (OE) strains and the wild-type strain. Heat map scale and gene identities are indicated. Hierarchical clustering was performed in Multiple Experiment Viewer (MeV) (http://mev.tm4.org/), using Pearson correlation with complete linkage clustering.