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1H NMR titration of lysine with tweezers. All signals show chemical shift perturbations and different degrees of line broadening. The protons that are located right inside the tweezer cavity upon binding experience the largest effects. The asterisk marks impurities in the tweezers stock solution. Reprinted (reproduced) with permission from [80], copyright (2017) Wiley-VCH Verlag GmbH & Co. KGaA.
