Table 1.

Summary of oxidatively modified mitochondrial proteins identified by redox proteomics and enzymatic activity in mild cognitive impairment (MCI) and Alzheimer disease (AD).

Protein	Oxidative Modification	Disease State	Brain Region	Activity	Reference
Aconitase	H	Late AD	Hippocampus	↓	[54]
MDH	H	Early AD	IPL	↑	[55]
LDH	H	MCI	Hippocampus	↓	[56]
ATP Synthase	H	MCI	Hippocampus	↓	[56]
	H	MCI	IPL	↓	[56]
	H	Early AD	IPL		[55]
	H	Late AD	IPL	↓	[54]
	N	Late AD	Hippocampus		[57]
MnSOD	H	Early AD	IPL	↓	[55]
	H	Late AD	IPL		[54]
EF-Tu	H	MCI	IPL		[56]
HSP70	H	MCI	Hippocampus		[56]
	N	MCI	Hippocampus		[58]
	C	MCI	IPL		[59]
HSP90	C	MCI	IPL		[60]
VDAC1	N	Late AD	Hippocampus		[57]

C, carbonylation; N, nitration; H, HNE bound.