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. 2020 Aug 26;10(9):636. doi: 10.3390/diagnostics10090636

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Motion correction of in vivo µCT to improve image quality and dose exposure. Respiratory-gated 4D µCT reconstructions of a mouse with a respiratory window width of 20%. The top row shows reconstructions obtained with the full dose of the used reference protocol (A,B) and the bottom row shows reconstructions obtained using only 20% of the reference dose (C,D). The standard reconstruction (FBP) results in severe artifacts if dose is reduced while a motion compensation (MoCo) approach results in an image quality sufficient for most qualitative and quantitative tasks (D). (C = 50 HU, W = 400 HU). Videos are available as a supplementary: Video S1a and S1b.