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. 2020 Sep 10;21(18):6639. doi: 10.3390/ijms21186639

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Peripheral cannabinoid receptor 1 (CB1R) antagonist increased lipolysis. 3T3-L1 adipocytes were treated with AM6545, rimonabant (RIM), and isoproterenol (ISO) for 4 and 48 h. (a) AM6545 increased glycerol and free fatty acid (FFA) releases into the media. (b) AM6545 increased genes involved in lipolysis such as hormone-sensitive lipase (Hsl), adipose triglyceride lipase (Atgl), and beta-3-adrenergic receptor (β3R). Data on graphs are presented as mean ± SEM of 4 independent rounds of the cells; * p < 0.05 vs. control ** p < 0.01 vs. control *** p < 0.001 vs. control.