Lung
|
References
|
Diffuse alveolar damage (histological hallmark of SARS-CoV-2 infection) |
[15,16,17,18,19,20,21,22,23,24] |
Focal vasculitis and capillaritis associated to microthrombosis as direct viral effect |
|
Thrombosis of large and medium-size pulmonary, related to SARS-COV-2-associated coagulopathy (likely secondary to an endothelial damage related to direct viral infection of the endothelial cells) or deriving from the deep veins of the lower extremities. Superimposed bronchopneumonia as result of bacterial superinfection |
|
Heart
|
|
Myocardial damage and myocarditis associated with increase in troponin levels, related to (a) direct myocardial infection by SARS-CoV-2 (b) hypoxemia due to respiratory failure and (c) inflammatory response correlated to the severe systemic inflammation status. Acute vasculitis of the intramyocardial vessels |
[25,26,27,28,29,30] |
Kidney
|
|
Acute tubular injury involving mainly the proximal tubules, probably related to direct infection of kidney by SARS-CoV-2 |
[30,32] |
Skin
|
|
Urticarial rashes and papulovesicular exanthems (cause not yet known) |
[33,34,35,36,37,38,39,40] |
Livedoid purple lesions and acrocyanosis |
|
Kawasaki disease |
|
Central Nervous System
|
|
Aspecific acute hypoxic damage in the brain and cerebellum (molecular test in sections of brain tissue were positive for the virus, but not immunohistochemistry) |
[41] |
Liver
|
|
Sinusoidal dilatation with lymphocytic infiltration and steatosis (cause not yet known) |
[20] |
Adrenal
|
|
Acute fibrinoid necrosis of arterioles (cause not yet known) |
[42] |
Testis
|
|
Seminiferous tubular injury, mild lymphocytic inflammation (cause not yet known) |
[43] |