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. 2020 Sep 10;21(18):6642. doi: 10.3390/ijms21186642

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of GRA16 and irinotecan on the induction of apoptosis and cell cycle arrest in non-small-cell lung carcinoma (NSCLC). Cell viability, cell cycle arrest, and cell apoptosis were investigated in GRA16 cells before and after irinotecan treatment using the CCK-8 assay and FACS analysis. (A) Annexin V and propidium iodide (PI) staining without irinotecan treatment. (B) Annexin V and PI staining under irinotecan treatment. (C) Cell viability and cell count (trypan blue exclusion test) without irinotecan treatment. (D) Cell viability and cell count under irinotecan treatment. (E) Cell cycle analysis via FACS without irinotecan treatment. (F) Cell cycle analysis via FACS under irinotecan treatment. * significant at p < 0.05 between control and GRA16 cells; ^† significant at p < 0.05 between vector and GRA16 cells.