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BER/MMR-related proteins targeted in cancer therapy.
| BER/MMR | ||||
|---|---|---|---|---|
| Protein | Drug Name | Combined Treatment | Possible Synthetic Lethal Interaction | References |
| APE1 | E3330 | Bleomycin | PARP1 inhibition | [163,164,165,166,167,168] |
| POL-β | NSC666715 | Alkylating agents | MSH2/MLH1 inhibition | [169,170] |
For each target it is reported: name of the drugs currently in analysis; combination of target inhibition and classic anti-cancer therapy under study; possible synthetic lethality interaction; references.
