Table 6.
NER/FA-related proteins targeted in cancer therapy.
| NER/FA | ||||
|---|---|---|---|---|
| Protein | Drug Name | Combined Treatment | Possible Synthetic Lethal Interaction | References |
| ERCC1 | NSC16168 | Cisplatin | PARP1 inhibition | [174,175,176,177,178] |
| FANCS | Phenylbutyrate | Cisplatin | [179] | |
| FANCD2 | Curcumin | Cisplatin | ATM inhibition CHK1 inhibition |
[124] |
| MLN4924 | DNA cross-linking agents | [180,181,182] | ||
| USP1/UAF1 | ML323 | Topoisomerase I and II inhibitors | PARP1 inhibition | [183,184] |
For each target it is reported: name of the drugs currently in analysis; combination of target inhibition and classic anti-cancer therapy under study; possible synthetic lethality interaction; references.