Table 1.
Patients characteristics with Gensini score below (<40) and above median (≥40) and risk alleles frequencies.
| Parameters | Total | Gensini <40 | Gensini ≥40 | p Value | |
|---|---|---|---|---|---|
| n = 1099 | n = 540 (49.1%) | n = 559 (50.9%) | |||
| Age (years): mean ± SD | 64.2 ± 9.4 | 63.9 ± 9.5 | 64.5 ± 9.4 | ns a | |
| median (min, max), n | 65 (36, 87), 1094 | 64.5 (36, 87), 538 | 65.5 (36, 84), 556 | ||
| Male: n (%) | 726 (66.1%) | 327 (60.6%) | 399 (71.5%) | 0.0001 b | |
| BMI (kg/m2): mean ± SD | 28.0 ± 4.1 | 27.9 ± 4.1 | 28.1 ± 4.0 | ns a | |
| median (min, max), n | 27.7 (14.9, 42.8), 1047 | 27.7 (14.9, 42.8), 516 | 27.7 (16.6, 40.9), 531 | ||
| Hypertension: n (%) | 856 (81.1%) | 419 (80.7%) | 438 (81.4%) | ns b | |
| Diabetes: n (%) | 265 (25.0%) | 132 (25.3%) | 133 (24.7%) | ns b | |
| Total cholesterol (mg/dL): mean ± SD | 207.1 ± 51.6 | 206.8 ± 50.1 | 207.3 ± 53.0 | ns a | |
| median (min, max), n | 198 (92, 552), 983 | 198 (98, 417), 486 | 198 (92, 552), 497 | ||
| LDL cholesterol (mg/dL): mean ± SD | 123.3 ± 43.8 | 122.4 ± 43.4 | 124.2 ± 44.3 | ns a | |
| median (min, max), n | 116 (7, 452), 905 | 115 (7, 317), 447 | 117 (37, 452), 458 | ||
| HDL cholesterol (mg/dL): mean ± SD | 54.8 ± 14.5 | 56.6 ± 16.1 | 52.9 ± 12.4 | 0.001 a | |
| median (min, max), n | 52 (26, 175), 956 | 53 (26, 175), 480 | 51 (26, 141), 489 | ||
| Triglycerides (mg/dL): mean ± SD | 147.2 ±94.8 | 144.8 ± 98.4 | 149.5 ± 91.1 | ns a | |
| median (min, max), n | 124 (36, 897), 975 | 122.5 (42, 897), 482 | 128 (36, 878), 493 | ||
| History of smoking: n (%) | 678 (67.0%) | 316 (63.2%) | 362 (70.7%) | 0.011 b | |
| CAD in family: n (%) | 546 (54%) | 267 (53.9%) | 279 (54.0%) | ns b | |
| Coronary narrowings ≥50% n (%) | 1070 (97.4%) | 511 (94.6%) | 559 (100%) | <0.0001 b | |
| Coronary narrowings ≥70% n (%) | 990 (90.1%) | 431 (79.8%) | 559 (100%) | <0.0001 b | |
| SNP | Risk allele | Risk allele frequency | |||
| PON1 c.575 A>G | G | 0.270 | 0.250 | 0.291 | 0.035 b |
| MPO c.−463 A>G | A | 0.164 | 0.157 | 0.170 | ns b |
| SOD2 c.47C>T | T | 0.476 | 0.462 | 0.490 | ns b |
| GCLM c.588 C>T | T | 0.165 | 0.166 | 0.165 | ns b |
| eNOS c.894 G>T | T | 0.277 | 0.269 | 0.284 | ns b |
| eNOS c.−786 C>T | C | 0.364 | 0.352 | 0.377 | ns b |
| CYBA c.214 T>C | T | 0.346 | 0.342 | 0.351 | ns b |
| CYBA c.−930 G>A | G | 0.596 | 0.590 | 0.602 | ns b |
ns: non statistically significant; n: number of subjects included into analysis; SD: standard deviation; BMI: Body mass index; LDL: low-density lipoprotein; HDL: high-density lipoprotein; CAD: coronary artery disease; SNP: single nucleotide polymorphism; a—Wilcoxon rank-sum test, b—Pearson’s chi-squared test.