Table 2.
Odds ratios of Gensini scores ≥40 occurrence in relation to selected genotypes and genetic risk score (GRS) groups.
| SNPs/GRS | Genotype/GRS Group | Gensini Score <40 (% of Genotype Carriers) |
Gensini Score ≥40 (% of Genotype Carriers) |
OR (95% CI), p |
|---|---|---|---|---|
| rs662 PON1 c.575A>G |
AA | 299 (55.7) | 275 (49.6) | 1 (Ref) |
| AG | 208 (38.7) | 236 (42.6) | 1.23 (0.96–1.58), p = 0.097 | |
| GG | 30 (5.6) | 43 (7.8) | 1.55 (0.95–2.55), p = 0.076 | |
| p for trend = 0.028 | ||||
| A allele (ref) vs. GG | 1.42 (0.88–2.30), p = 0.151 | |||
| AA (ref) vs. G allele | 1.27 (1.004–1.617), p = 0.046 | |||
| rs2333227 MPO c.−463A>G |
GG | 375 (69.8) | 385 (69.5) | 1 (Ref) |
| GA | 155 (28.9) | 150 (27.1) | 0.94 (0.72–1.22), p = 0.663 | |
| AA | 7 (1.3) | 19 (3.4) | 2.64 (1.10–6.36), p = 0.025 | |
| p for trend = 0.432 | ||||
| A allel vs. GG (ref) | 1.02 (0.78–1.31), p = 0.903 | |||
| AA vs. G allel (ref) | 2.69 (1.12–6.45), p = 0.021 | |||
| rs4880 SOD2 c.47C>T |
CC | 148 (27.6) | 147 (26.5) | 1 (Ref) |
| CT | 282 (52.5) | 271 (48.9) | 0.97 (0.73–1.28), p = 0.828 | |
| TT | 107 (19.9) | 136 (24.6) | 1.28 (0.91–1.79), p = 0.156 | |
| p for trend = 0.183 | ||||
| T allele vs. CC (ref) | 1.05 (0.81–1.37), p = 0.703 | |||
| TT vs. C allele (ref) | 1.31 (0.98–1.74), p = 0.067 | |||
| rs41303970 GCLM c.588C>T |
CC | 376 (70.0) | 387 (69.9) | 1 (Ref) |
| CT | 144 (26.8) | 151 (27.2) | 0.99 (0.77–1.28), p = 0.945 | |
| TT | 17 (3.2) | 16 (2.9) | 1.13 (0.76–1.66), p = 0.548 | |
| p for trend = 0.972 | ||||
| T allele vs. CC (ref) | 1.00 (0.78–1.31), p = 0.953 | |||
| TT vs. C allele (ref) | 0.91 (0.45–1.82), p = 0.789 | |||
| rs1799983 eNOS c.894G>T |
GG | 290 (53.8) | 282 (51.0) | 1 (Ref) |
| GT | 208 (38.6) | 228 (41.2) | 1.13 (0.88–1.45), p = 0.346 | |
| TT | 41 (7.6) | 43 (7.8) | 1.08 (0.68–1.71), p = 0.746 | |
| p for trend = 0.437 | ||||
| GG (ref) vs. T allele | 1.12 (0.88–1.42), p = 0.353 | |||
| G allele (ref) vs. TT | 1.02 (0.66–1.60), p = 0.917 | |||
| rs2070744 eNOS c.−786C>T |
TT | 223 (42.7) | 214 (40.1) | 1 (Ref) |
| CT | 231 (44.3) | 236 (44.3) | 1.06 (0.82–1.38), p = 0.638 | |
| CC | 68 (13.0) | 83 (15.6) | 1.27 (0.88–1.84), p = 0.204 | |
| p for trend = 0.232 | ||||
| CC vs. T allele (ref) | 1.23 (0.87–1.74), p = 0.238 | |||
| C allele vs. TT (ref) | 1.11 (0.87–1.42), p = 0.397 | |||
| rs4673 CYBA c.214T>C |
CC | 230 (43.3) | 234 (42.9) | 1 (Ref) |
| CT | 239 (45.0) | 241 (44.1) | 0.99 (0.77–1.28), p = 0.945 | |
| TT | 62 (11.7) | 71 (13.0) | 1.13 (0.76–1.66), p = 0.548 | |
| p for trend = 0.666 | ||||
| T allele vs. CC (ref) | 1.02 (0.80–1.30), p = 0.880 | |||
| TT vs. C allele (ref) | 1.13 (0.79–1.63), p = 0.508 | |||
| rs9932581 CYBA c.−930G>A |
AA | 84 (16.0) | 93 (17.0) | 1 (Ref) |
| AG | 262 (50.0) | 248 (45.4) | 0.85 (0.61–1.2), p = 0.369 | |
| GG | 178 (34.0) | 205 (37.6) | 1.04 (0.73–1.49), p = 0.828 | |
| p for trend = 0.546 | ||||
| A allele (ref) vs. GG | 1.17 (0.91–1.50), p = 0.222 | |||
| AA (ref) vs. G allele | 0.93 (0.67–1.28), p = 0.659 | |||
| Genetic Risk Score (GRS) |
1~2 | 40 (7.9) | 26 (5.0) | 1 (Ref) |
| 3~4 | 147 (29.1) | 147 (28.2) | 1.53 (0.89–2.67), p = 0.119 | |
| 5~6 | 205 (40.5) | 194 (37.2) | 1.45 (0.86–2.50), p = 0.164 | |
| 7~8 | 93 (18.4) | 120 (23.1) | 1.98 (1.13–3.51), p = 0.016 | |
| 9~12 | 21 (4.1) | 34 (6.5) | 2.47 (1.19–5.23), p = 0.014 | |
| p value for trend 0.008 |
T allele = TT genotype + CT genotype; C allele = CC genotype + CT genotype; A allele = AA genotype + AG genotype; G allele = GG genotype + AG genotype; OR: odds ratio; CI: confidence interval. Bold font indicates statistical significance.