Table 3.
Association between risk factors and Gensini score.
| PARAMETERS | GENSINI SCORE | |||||
|---|---|---|---|---|---|---|
| Univariate Analysis | Multivariate Regression Analysis | |||||
| Spearman’s Rank Correlation Rho ρ | p Value | PON1 Model | GRS Model | |||
| β | p Value for F test | β | p Value for F test | |||
| Age (years) | 0.038 | 0.212 | 0.031 | 0.004 | 0.031 | 0.006 |
| Male sex (%) | 0.151 | <0.0001 | 0.965 | <0.0001 | 0.907 | <0.0001 |
| BMI (kg/m2) | −0.008 | 0.787 | - | - | - | - |
| Hypertension (%) | −0.019 | 0.535 | - | - | - | - |
| Diabetes (%) | −0.020 | 0.523 | - | - | - | - |
| Total cholesterol (mg%) | 0.013 | 0.673 | 0.007 | 0.001 | 0.007 | 0.003 |
| LDL cholesterol (mg%) | 0.039 | 0.236 | - | - | - | - |
| HDL cholesterol (mg%) | −0.116 | 0.0003 | −0.036 | <0.0001 | −0.037 | <0.0001 |
| Triglycerides (mg%) | 0.074 | 0.021 | - | - | - | - |
| History of smoking (%) | 0.093 | 0.003 | - | - | - | - |
| PON1 c.575A>G | 0.069 | 0.022 | 0.43 | 0.007 | NA | NA |
| GRS | 0.068 | 0.030 | NA | NA | 0.128 | 0.014 |
ns: non-significant; NA: non-analysed; BMI: Body mass index; LDL: low-density lipoprotein cholesterol; HDL: high-density lipoprotein cholesterol; CAD: coronary artery disease; β: partial regression coefficient, GRS: genetic risk score (total number of risk alleles); PON1 c.575A>G: AA = 0, AG = 1, GG = 2; Variables were considered for the multivariate regression model when their simple linear regression p value was < 0.05. While applying a bidirectional elimination approach to stepwise multivariate regression, LDL cholesterol and triglyceride level were excluded due to severe multicollinearity with the total cholesterol; BMI, hypertension, diabetes, and smoking status were excluded and found not to be confounding variables in our models; p value for F test is the p-value for ANOVA to test whether the more complex model (including given variable) is significantly better than the simpler model (excluding given variable). Bold font indicates statistical significance.