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Cinobufagin decreases LEF1 expression in melanoma cells. (A–C) Cinobufagin suppresses nuclear LEF1 protein levels in a dose-dependent manner in A375 (A), G361 (B), and A2058 (C) melanoma cells. Cells were incubated for 24 h with different concentrations of cinobufagin as indicated. After cinobufagin treatment, nuclear protein was isolated and protein levels were measured by Western blotting.
