Figure 4.
Cancer stem cell (CSC)-like SKOV3 spheres transduced with cluster of differentiation 133 (CD133) promoted tumor growth in a xenograft mice model. SKOV3 spheres with CD133 transduction (SP-CD133), SKOV3 spheres with mock-transduction (SP-Mock), and parental SKOV3 (SKOV3-P) cells were subcutaneously (s.c.) implanted into NOD/SCID mice. (A) Detailed treatment schedule of the in vivo study is shown. (B) Tumor volumes (cm3) during the subsequent period (n = 6 per group; * p < 0.05; *** p < 0.001). (C) Body weights during the subsequent period. (D) Gross images of dissected tumors at the study endpoint. (E) Mean tumor volumes (cm3) plotted in a bar graph, and mean tumor weights (mg) expressed in line plots from each mouse group at the study endpoint (n = 6 per group; * p < 0.05; *** p < 0.001).