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. 2020 Sep 4;21(18):6467. doi: 10.3390/ijms21186467

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Overexpression of cluster of differentiation 133 (CD133) in SKOV3 spheres with CD133 transduction (SP-CD133) induced the reduction of extracellular matrix (ECM) receptor interactions/focal adhesion and promoted cell cycle progression. (A) The heatmap of the differentially expressed genes (DEGs) extracted from the three SKOV3-related modules including SP-CD133, SKOV3 spheres with mock-transduction (SP-Mock), and parental SKOV3 (SKOV3-P) cells. (B) KEGG pathway enrichment analysis of all DEGs. (C) Simplified diagram of key factors/pathways modulated by CD133. (D) Representative RT-qPCR analysis comparing expression levels of ITGA6, ITGB8, PIK3CA, FOXO3, RBL2, FasL, Bcl2, GPCR, CREB, LRP5, and TCF. Data shown were acquired from three independent experiments. * p < 0.05; ** p < 0.01; *** p < 0.001, ns: not significant.

Overexpression of cluster of differentiation 133 (CD133) in SKOV3 spheres with CD133 transduction (SP-CD133) induced the reduction of extracellular matrix (ECM) receptor interactions/focal adhesion and promoted cell cycle progression. (A) The heatmap of the differentially expressed genes (DEGs) extracted from the three SKOV3-related modules including SP-CD133, SKOV3 spheres with mock-transduction (SP-Mock), and parental SKOV3 (SKOV3-P) cells. (B) KEGG pathway enrichment analysis of all DEGs. (C) Simplified diagram of key factors/pathways modulated by CD133. (D) Representative RT-qPCR analysis comparing expression levels of ITGA6, ITGB8, PIK3CA, FOXO3, RBL2, FasL, Bcl2, GPCR, CREB, LRP5, and TCF. Data shown were acquired from three independent experiments. * p < 0.05; ** p < 0.01; *** p < 0.001, ns: not significant.