Table 2.

Fractional anisotropy (FA) and mean diffusivity (MD) for different ROIs in the subjects with CSVD and the controls.

ROI	FA (Mean ± SD)		p	MD (Mean ± SD)		p
	CSVD (n = 74)	Control (n = 18)		CSVD (n = 74)	Control (n = 18)
Anterior frontal
jcNAWM	33.14 ± 7.99	29.03 ± 7.74	0.023	9.26 ± 0.73	10.29 ± 0.97	<0.001
dNAWM	33.29 ± 10.04	28.55 ± 6.97	0.014	9.12 ± 0.82	10.05 ± 1.16	<0.001
pvNAWM	27.15 ± 8.94	34.15 ± 11.49	0.047	9.32 ± 0.82	10.09 ± 1.44	0.041
Posterior frontal
jcNAWM	35.86 ± 7.52	35.89 ± 9.28	0.919	9.50 ± 0.75	10.18 ± 1.16	0.015
dNAWM	34.29 ± 7.10	34.16 ± 8.16	0.646	8.67 ± 0.78	9.69 ± 1.09	<0.001
pvNAWM	36.80 ± 9.78	27.67 ± 9.38	0.004	8.64 ± 0.80	11.45 ± 2.34	<0.001
Temporoparietal
jcNAWM	43.84 ± 7.78	35.26 ± 10.35	0.002	8.58 ± 0.54	9.78 ± 1.25	<0.001
dNAWM	34.37 ± 7.22	35.28 ± 10.83	0.935	9.43 ± 1.14	9.67 ± 1.21	0.584
pvNAWM	47.74 ± 7.89	50.69 ± 12.67	0.256	9.38 ± 0.52	10.19 ± 1.38	0.022
Anterior CB
left	46.69 ± 8.38	39.47 ± 10.42	0.017	9.41 ± 1.17	10.25 ± 1.13	0.019
right	46.32 ± 9.11	41.06 ± 11.89	0.059	8.69 ± 1.10	9.86 ± 1.28	0.001
Middle CB
left	58.86 ± 10.96	49.12 ± 12.41	0.005	8.46 ± 0.88	9.29 ± 1.17	0.002
right	54.57 ± 11.89	49.28 ± 11.42	0.068	8.55 ± 0.97	9.09 ± 1.42	0.106
Posterior CB
left	35.81 ± 11.77	33.79 ±1 3.61	0.370	10.22 ± 4.34	9.62 ± 1.25	0.306
right	37.03 ± 18.91	33.30 ± 12.46	0.466	9.19 ± 1.08	9.65 ± 1.67	0.121
Anterior CC	90.93 ± 4.82	76.83 ± 14.81	<0.001	7.48 ± 0.76	9.41 ± 2.52	0.002
Mid-anterior CC	61.48 ± 7.92	46.35 ± 14.77	<0.001	11.36 ± 1.69	13.65 ± 3.17	0.004
Mid-posterior CC	57.61 ± 13.49	48.25 ± 15.21	0.040	12.16 ± 1.98	14.99 ± 3.90	0.022
Posterior CC	86.99 ± 4.13	79.35 ± 12.54	0.018	8.53 ± 1.04	9.79 ± 2.23	0.004
Hippocampus
left	30.51 ± 9.45	30.68 ± 8.69	0.946	10.82 ± 1.50	10.88 ± 1.77	0.899
right	31.34 ± 7.16	30.09 ± 9.59	0.858	10.29 ± 1.05	10.67 ± 1.91	0.273

Abbreviations and notes: values in bold are statically significant differences. FA—fractional anisotropy (×10⁻²); MD—mean diffusivity (mm²/s × 10⁻⁴); jcNAWM—juxtacortical normal appearing white matter, dNAWM—deep normal appearing white matter, pvNAWM—periventricular normal appearing white matter, CB—cingulum bundle, CC—corpus callosum.