Table 3.
ROI | AD (Mean ± SD) | p | RD (Mean ± SD) | p | ||
---|---|---|---|---|---|---|
CSVD (n = 74) |
Control (n = 18) |
CSVD (n = 74) |
Control (n = 18) |
|||
Anterior frontal | ||||||
jcNAWM | 12.52 ± 1.14 | 13.38 ± 1.29 | <0.001 | 7.62 ± 0.91 | 8.75 ± 1.17 | 0.017 |
dNAWM | 12.19 ± 1.13 | 12.99 ± 1.26 | 0.001 | 7.58 ± 0.94 | 8.59 ± 1.01 | 0.008 |
pvNAWM | 11.94 ± 0.92 | 13.87 ± 2.18 | 0.001 | 8.01 ± 1.09 | 8.20 ± 1.66 | 0.582 |
Posterior frontal | ||||||
jcNAWM | 13.19 ± 1.20 | 14.06 ± 1.59 | 0.064 | 7.65 ± 0.85 | 8.24 ± 1.32 | 0.026 |
dNAWM | 11.83 ± 1.03 | 13.21 ± 1.55 | 0.005 | 7.09 ± 0.88 | 7.94 ± 1.19 | 0.002 |
pvNAWM | 12.39 ± 0.82 | 14.71 ± 2.34 | <0.001 | 6.76 ± 1.22 | 9.82 ± 2.53 | <0.001 |
Temporoparietal | ||||||
jcNAWM | 12.77 ± 1.21 | 13.48 ± 1.48 | <0.001 | 6.48 ± 0.69 | 7.93 ± 1.55 | 0.053 |
dNAWM | 12.98 ± 1.45 | 13.35 ± 1.57 | 0.754 | 7.66 ± 1.16 | 7.84 ± 1.47 | 0.618 |
pvNAWM | 14.45 ± 1.72 | 16.45 ± 2.61 | 0.730 | 6.85 ± 0.76 | 7.05 ± 1.68 | 0.636 |
Anterior CB | ||||||
left | 14.57 ± 1.59 | 14.79 ± 1.74 | 0.010 | 6.83 ± 1.49 | 7.98 ± 1.35 | 0.798 |
right | 13.45 ± 1.65 | 14.45 ± 1.96 | 0.002 | 6.31 ± 1.20 | 7.56 ± 1.63 | 0.001 |
Middle CB | ||||||
left | 14.46 ± 2.52 | 14.78 ± 2.29 | 0.005 | 5.46 ± 1.15 | 6.54 ± 1.41 | 0.630 |
right | 14.39 ± 2.19 | 14.45 ± 2.63 | 0.917 | 5.63 ± 1.13 | 6.40 ± 1.41 | 0.976 |
Posterior CB | ||||||
left | 14.03 ± 4.35 | 13.38 ± 2.25 | 0.545 | 8.31 ± 4.53 | 7.74 ± 1.59 | 0.608 |
right | 13.05 ± 2.60 | 13.39 ± 2.31 | 0.201 | 7.26 ± 1.88 | 7.78 ± 1.57 | 0.290 |
Anterior CC | 19.26 ± 1.79 | 19.85 ± 2.43 | 0.259 | 1.62 ± 0.77 | 4.19 ± 3.09 | 0.454 |
Mid-anterior CC | 20.41 ± 2.46 | 20.94 ± 2.29 | 0.407 | 6.83 ± 1.61 | 9.99 ± 3.86 | 0.355 |
Mid-posterior CC | 20.91 ± 2.24 | 23.36 ± 2.89 | <0.001 | 7.79 ± 2.49 | 10.81 ± 4.67 | 0.010 |
Posterior CC | 20.34 ± 1.81 | 21.26 ± 2.21 | 0.075 | 2.62 ± 1.37 | 4.05 ± 2.68 | 0.098 |
Hippocampus | ||||||
left | 14.35 ± 1.31 | 14.51 ± 1.85 | 0.678 | 9.06 ± 1.84 | 9.06 ± 2.01 | 0.976 |
right | 13.93 ± 1.51 | 14.15 ± 1.98 | 0.609 | 8.48 ± 1.07 | 8.92 ± 2.12 | 0.393 |
Abbreviations and notes: values in bold are statically significant differences. AD—axial diffusivity (mm2/s × 10−4); RD—radial diffusivity (mm2/s × 10−4); jcNAWM—juxtacortical normal appearing white matter, dNAWM—deep normal appearing white matter, pvNAWM—periventricular normal appearing white matter, CB—cingulum bundle, CC—corpus callosum.