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. 2020 Sep 22;9(9):904. doi: 10.3390/antiox9090904

Figure 8.

Figure 8

Correlation between KEAP1 CpGs methylation and transcript levels of NRF2 or its target genes in LUAD and LUSC cohorts. The KEAP1 gene structure is shown in the middle, including exons (sky blue boxes) and introns (brown boxes), as well as its two CpG islands: CGI-1 and CGI-2 (both underlined with green bars). A total of 16 CpG sites, marked with green circles, are indicated from 5′ to 3′ genomic localization (listed below). A filled rhombus, corresponding to a KEAP1 CpG site, depicts a significant inverse (blue square) or direct (red square) correlation (R ≤ −0.1; p < 0.05) between methylation and transcript levels of NRF2 or its target genes in LUAD (A) and particularly in LUSC (B), in contrast to an empty rhombus indicating no significant correlation. Abbreviations: EX, exon; Intr, intron; CGI-1, CpG Island 1; CGI-2, CpG Island 2; LUSC, lung squamous cell carcinoma; LUAD, lung adenocarcinoma; No-mts, non-metastatic disease stages.