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Sema4A-PlexinD1 axis inhibits Th1 and promotes Th2 and Th17 differentiation. Cytokines mRNA expression in naïve CD4+ T cells differentiated either in medium (Med), Th1, Th2 or Th17 differentiation cocktails in the presence of an anti-PlexinD1 antibody or its respective isotype control for 7 days (n = 6). Data is presented as connected dots. * p < 0.05. # p < 0.05 and ## p < 0.01 compared to the medium.
