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Genotyping and efficacy of Aldehyde dehydrogenase 2*2 knock-in (ALDH2*2 KI) mice. (A) Founder (lane marked by the box) mice containing the KI allele were confirmed by sub-cloning and direct sequencing analysis. [A], G-to-A substitution (B) Decreased ALDH2 enzymatic activities in the livers of the ALDH2*2 KI mice. (C) Decreased ALDH2 protein expression in the heart tissues of the ALDH2*2 KI mice. WT, wild-type; Mt, mutant; RE, restriction enzyme; * p < 0.05, ** p < 0.01, *** p < 0.001.
