Table 2.
Gene description and fold change of top 10 deregulated RNAs after transcriptome analysis.
| Gene Name | log2FC | Gene Description |
|---|---|---|
| Clcf1 | 7.45 | Protein that in complexation with CRLF1 forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development. Stimulates B-cells. Binds to and activates the ILST/gp130 receptor. |
| Ceacam1 | −7.25 | Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner. Plays a role as coinhibitory receptor in immune response and insulin action, and is an activator of angiogenesis. Downregulates cell growth in response to EGF through its interaction with SHC1. Inhibits cell migration and cell scattering through interaction with FLNA, interfering with FLNA’s interaction with RALA. |
| St18 | 7.21 | Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5′-AAAGTTT-3′ separated by 2–9 nucleotides. |
| Slc38a1 | −7.19 | Functions as a sodium-dependent amino acid transporter. May supply glutamatergic and GABAergic neurons with glutamine, which is required for the synthesis of the neurotransmitters, e.g., glutamate and GABA |
| Sema3e | 7.05 | Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. |
| Actl7b | 6.35 | Actin-like protein 7B, belongs to the actin family |
| Scrt2 | 6.14 | Transcriptional repressor scratch 2; plays a role in DNA binding and negative regulation of transcription |
| Aldh1a3 | 5.69 | NAD-dependent aldehyde dehydrogenase that catalyzes the formation of retinoic acid |
| Fgl1 | −5.64 | Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3 |
| Lhx6 | 5.63 | Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex |
Protein function description was obtained from the UniProtKB database (https://www.uniprot.org/uniprot).